Biophysics of a Trespasser

Biophysics of a Trespasser

Why were Hodgkin and Huxley so disappointed with their work? Through a brilliant train of thought that considered the linearity of the current-voltage curve and the relative amplitudes of ionic and gating currents (Hodgkin and Huxley, 1952), they concluded that the Na 1 current which drives the action potential passes through a channel—defined as a pore that passes ions at high rates compared t...

Biophysics.

A puzzle in DNA biophysics.

In this issue, Lee et al. report the experimental temperature-dependence of the unzipping force for two natural DNA sequences. For both sequences, the curves show an anomaly at temperatures around 40 degrees C. In this brief contribution, we stress that the anomaly is not easily explained within the established theoretical models for the biophysics of DNA. As this puzzle questions our basic und...

Correction to 'Biophysics of protein evolution and evolutionary protein biophysics'.

References http://rsif.royalsocietypublishing.org/content/11/100/20140419.full.html#ref-list-1 This article cites 435 articles, 131 of which can be accessed free Subject collections (313 articles) computational biology • (354 articles) biophysics • (49 articles) bioinformatics • Articles on similar topics can be found in the following collections Email alerting service here right-hand corner...

Computational Biophysics

Introduction/Group Overview The RLE Computational Biophysics Group is focused on understanding conformational changes in biomolecules that play an important role in common human diseases. The group uses an interdisciplinary approach combining computational modeling with biochemical experiments to make connections between conformational changes in macromolecules and disease progression. By emplo...